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Year : 2019  |  Volume : 2  |  Issue : 2  |  Page : 21-25

Vitamin D in rheumatoid arthritis and association of disease activity with various laboratory parameters

1 Department of Orthopaedics, NMCH, Patna, Bihar, India
2 Department of Orthopaedics, Ayushman Hospital, Hajipur, Bihar, India

Correspondence Address:
Dr. Ravi Kumar
Department of Orthopaedics, NMCH, Agamkuan, Patna - 800 007, Bihar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JODP.JODP_7_19

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Background: The aim was to validate the association between Vitamin D level and rheumatoid arthritis (RA); evaluate association of stages of disease activity with various parameters such as serum Vitamin D level, RA factor level, anti-cyclic citrullinated peptide (CCP), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels; and evaluate correlation of Vitamin D with various parameters and Disease Activity Score (DAS)-28 score with various parameters. Materials and Methods: This was a prospective comparative study. The sample size was of 100 patients with 50 each in case and control groups. Investigations such as ESR, CRP (quant), anti-CCP, and RA factor were undertaken for case group. Serum 25-hydroxyvitamin D concentration was analyzed for both case and control groups. Disease activity was measured in patients of RA using DAS-28. Mean of Vitamin D level in case and control groups were measured. Association of different stage of disease activity among cases was calculated with various laboratory parameters. Correlation coefficient of Vitamin D with various laboratory parameters and DAS-28 score with various laboratory parameters calculated. Results: The mean Vitamin D level in case group was 18.726 ng/ml, while in control group, it was 42.851 ng/ml. Association of various stages of disease activity was statistically highly significant for CRP and anti-CCP levels. Vitamin D was negatively correlated with serum ESR, while DAS-28 score was positively correlated with serum ESR, CRP, RA factor, and anti-CCP values. Conclusions: Vitamin D deficiency is more common in RA patients. CRP and anti-CCP markers are associated with disease activity. Moderate-to-strong positive linear correlation present between DAS 28 score & CRP and DAS 28 score & anti CCP values respectively.

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